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Reported observations include: Temporary injection site irritation Mild redness Temporary swelling Local discomfort Mild headache Researchers continue examining long-term biological responses across different laboratory models

The evidence is promising but limited

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As demonstrated for MOR and DOR, KOR also undergoes an arrestin-dependent sequestration when activated by U50,488 as shown by the reduction of internalization when the dominant negative mutant arrestin 2 319418 is over-expressed (Li et al., 1999)